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Alzheimer's Disease

Easterseals and the Brain Plasticity Institute: Working Together

The Issue

Taking on Alzheimer’s disease

Easterseals has engaged the San Francisco-based Brain Plasticity Institute in collaboration with the brain fitness company Posit Science Corporation, to help us develop:

The Brain Plasticity Institute: Project Scope

From a brain plasticity perspective, it should be possible to substantially delay the onset of and, with significant probability, prevent Alzheimer’s disease. Here, we describe a brain plasticity based approach designed to re-activate and thereby re-vascularize brain areas whose dysfunction and immunological compromise are strongly linked to disease genesis. Our training program would also upregulate, through intensive training, the production and release of a key neurotransmitter, noradrenaline,1 known to promote stronger immune response activity in the brain. Our therapeutic strategy would also broadly grow and restore functional and physical brain processes known to underlie declines in ability among older-aged individuals known to be at risk for "mild cognitive impairment," and for Alzheimer's disease itself.

To implement this strategy, we shall build the elaborate tool set -- much of which is in hand, and has already been demonstrated to drive key behavioral and neurological changes -- required to assess levels of risk in -- then intensively train -- adult individuals of all ages. We shall then conduct large scale internet trials among individuals known to be genetically at risk for Alzheimer’s onset at a relatively young age and in the broader senior population, with sensitivity to a long list of neurological or psychiatric burdens that may contribute to greater risks of AD onset.

Our goal is to increase the brain spans of older individuals so that they come closer to matching their lifespans. The accomplishment of this goal for the hundreds of millions of individuals in need of help can positively transform the course of aging in America and in the world. As medicine prolongs the average human life, the assured prolongation of an active, effective brain, capable of sustaining cognitive, social and action-control abilities, our happiness, and our thriving independence is one of our greatest personal and societal needs.

We strongly believe that this does not have to happen.

Help us help scientists and technologists at the Brain Plasticity Institute and Posit Science meet this great human challenge.

  1. Also called ‘norepinephrine’
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